benzodiazepine receptor (BZR) ligand. Acts as an agonist at α2
and antagonist at α1
benzodiazepine receptors (Ki
values are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.
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Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor.
Taliani et al.