TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate immune function, proliferation and epithelial-mesenchymal transition.TGF-beta associates with LAP after secretion, and this complex is covalently linked to one of three latent TGF-beta binding proteins (LTBPs). TGF-beta is activated from latency by Plasmin, matrix metalloproteases, Thrombospondin 1, or a subset of integrins. TGF-beta signals through a complex of TGF-beta RII and either TGF-beta RI/ALK-5 or ALK-1. TGF-beta induced signaling is modulated by the accessory proteins Betaglycan/TGF-beta RIII and Endoglin.
TGF beta 1/2/3 Antibody (1D11R) [Janelia Fluor® 525]
Novus Biologicals | Catalog # FAB1835RJF525
Recombinant Monoclonal Antibody
Key Product Details
Species Reactivity
Multi-Species
Applications
Neutralization
Label
Janelia Fluor 525
Antibody Source
Recombinant Monoclonal Mouse IgG1 Clone # 1D11R
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Product Specifications
Immunogen
Bovine bone-derived TGF-beta 1 and TGF-beta 2
Specificity
Detects bovine, chicken, mouse, and human TGF-beta in ELISAs and Western blots. It recognizes human TGF-beta 1, TGF-beta 2, and TGF-beta 3.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Description
This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
Applications for TGF beta 1/2/3 Antibody (1D11R) [Janelia Fluor® 525]
Application
Recommended Usage
Neutralization
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Recommended applications are based on validated applications from the unconjugated base product MAB1835R. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from cell culture supernatant
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: TGF-beta 1, 2, 3
Long Name
Transforming Growth Factor beta 1, 2, and 3
Alternate Names
CED, DPD1, LAP, TGFB, TGFB1, TGFbeta, transforming growth factor, beta 1
Additional TGF-beta 1, 2, 3 Products
Product Documents for TGF beta 1/2/3 Antibody (1D11R) [Janelia Fluor® 525]
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for TGF beta 1/2/3 Antibody (1D11R) [Janelia Fluor® 525]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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Associated Pathways
