IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Click on one of the buttons below to see either the IL-9 signaling pathways or information related to one of the other common cytokine receptor gamma-chain family members.

IL-9
IL-9
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IL-9 R
IL-9 R
Regulates Activated
T Cell Proliferation
Regulates Activated
T Cell Proliferation
Activated
CD4+ T Cell
Activated
CD4+ T Cell

Proliferation/Survival

Proliferation/Survival

IL-9
IL-9
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IL-9
IL-9
IL-4
IL-4
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IL-4 R
IL-4 R
Regulates Immunoglobulin
Production
Regulates Immunoglobulin
Production
Activated B Cell
Activated B Cell
Plasma Cell
Plasma Cell

IgG1, IgG2A, IgG2B, IgE
Production

IgG1, IgG2A, IgG2B, IgE
Production

IL-9
IL-9
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IL-9 R
IL-9 R
IL-1 beta,
IL-1 beta,
IL-5,
IL-5,
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IL-6,
IL-6,
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IL-13,
IL-13,
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TGF-beta,
TGF-beta,
Proteases
Proteases
Promotes Mast Cell Proliferation
& Cytokine Secretion
Promotes Mast Cell Proliferation
& Cytokine Secretion
Mast Cell
Mast Cell

Proliferation

Proliferation

IL-9 R
IL-9 R
IL-9
IL-9
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IL-9 R
IL-9 R
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IL-9 R
IL-9 R
IL-9
IL-9
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IL-13
IL-13
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Promotes Mucus Production
Promotes Mucus Production
Mucus
Mucus
Lung Epithelial Cells
Lung Epithelial Cells
Mast Cells
Mast Cells
Th2 or Th9 Cells
Th2 or Th9 Cells

Mucus Production

Mucus Production

Overview of IL-9 Signaling and its Primary Biological Effects of IL-9 Signaling in Different Immune Cell Types

Interleukin-9 (IL-9) is a pleiotropic cytokine that is produced by activated T lymphocytes. It signals through a receptor complex consisting of IL-9 R and the common gamma-chain/IL-2 R gamma subunit. IL-9 was initially identified as a mouse T cell and mast cell growth factor. It has subsequently been shown to regulate immunoglobulin production by B cells, enhance mast cell protease expression, and promote goblet cell hyperplasia and mucus production, suggesting a link between IL-9 and the development of allergic inflammation. Although IL-9 was originally thought to be produced primarily by Th2 cells, naïve CD4+ T cells differentiate into a distinct IL-9-secreting T cell subset known as Th9 cells in the presence of IL-4 and TGF-beta. Th9 cells secrete IL-9 and IL-10 (in mice), but do not produce cytokines characteristic of other T helper subsets. Since the precise role of Th9 cells in the pathogenesis of allergic inflammation and other human diseases is not currently well understood, growing interest in this area will help to better define the effects of IL-9 signaling.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.

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