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IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Click on one of the buttons below to see either the IL-9 signaling pathways or information related to one of the other common cytokine receptor gamma-chain family members.

Click on one of the buttons below to highlight that portion of the pathway.
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
IL-9
IL-9
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IL-9 R
IL-9 R
Regulates Activated
T Cell Proliferation
Regulates Activated
T Cell Proliferation
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Activated
CD4+ T Cell
Activated
CD4+ T Cell
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Proliferation/Survival

Proliferation/Survival

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IL-9
IL-9
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IL-9
IL-9
IL-4
IL-4
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IL-4 R
IL-4 R
Regulates Immunoglobulin
Production
Regulates Immunoglobulin
Production
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Activated B Cell
Activated B Cell
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Plasma Cell
Plasma Cell
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IgG1, IgG2A, IgG2B, IgE
Production

IgG1, IgG2A, IgG2B, IgE
Production

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IL-9
IL-9
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IL-9 R
IL-9 R
IL-1 beta,
IL-1 beta,
IL-5,
IL-5,
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IL-6,
IL-6,
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IL-13,
IL-13,
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TGF-beta,
TGF-beta,
Proteases
Proteases
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Promotes Mast Cell Proliferation
& Cytokine Secretion
Promotes Mast Cell Proliferation
& Cytokine Secretion
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Mast Cell
Mast Cell
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Proliferation

Proliferation

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IL-9 R
IL-9 R
IL-9
IL-9
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IL-9 R
IL-9 R
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IL-9 R
IL-9 R
IL-9
IL-9
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IL-13
IL-13
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Promotes Mucus Production
Promotes Mucus Production
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Mucus
Mucus
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Lung Epithelial Cells
Lung Epithelial Cells
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Mast Cells
Mast Cells
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Th2 or Th9 Cells
Th2 or Th9 Cells
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Mucus Production

Mucus Production

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IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Overview of IL-9 Signaling and its Primary Biological Effects of IL-9 Signaling in Different Immune Cell Types

Interleukin-9 (IL-9) is a pleiotropic cytokine that is produced by activated T lymphocytes. It signals through a receptor complex consisting of IL-9 R and the common gamma-chain/IL-2 R gamma subunit. IL-9 was initially identified as a mouse T cell and mast cell growth factor. It has subsequently been shown to regulate immunoglobulin production by B cells, enhance mast cell protease expression, and promote goblet cell hyperplasia and mucus production, suggesting a link between IL-9 and the development of allergic inflammation. Although IL-9 was originally thought to be produced primarily by Th2 cells, naïve CD4+ T cells differentiate into a distinct IL-9-secreting T cell subset known as Th9 cells in the presence of IL-4 and TGF-beta. Th9 cells secrete IL-9 and IL-10 (in mice), but do not produce cytokines characteristic of other T helper subsets. Since the precise role of Th9 cells in the pathogenesis of allergic inflammation and other human diseases is not currently well understood, growing interest in this area will help to better define the effects of IL-9 signaling.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.

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