Chemical Name: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide
Biological ActivityTH 257 is a potent and selective allosteric LIMK 1/2 inhibitor (IC50 values are 84 and 39 nM, respectively). Inhibits cofilin phosphorylation in vitro. Exhibits no significant activity against the wider kinome.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials.
Manetti et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for TH 257
There are currently no reviews for this product. Be the first to review TH 257 and earn rewards!
Have you used TH 257?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image