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TH 257

Catalog #: 6899 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6899/5
6899/25
TH 257 | CAS No. 2244678-29-1 | LIMK Inhibitors
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Description: Potent and selective allosteric LIMK 1/2 inhibitor

Chemical Name: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide

Purity: ≥98%

Product Details
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Biological Activity

TH 257 is a potent and selective allosteric LIMK 1/2 inhibitor (IC50 values are 84 and 39 nM, respectively). Inhibits cofilin phosphorylation in vitro. Exhibits no significant activity against the wider kinome.

Technical Data

M.Wt:
422.54
Formula:
C24H26N2O3S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2244678-29-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TH 257 probe summary on the SGC website.

Product Datasheets

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