TRAF-3 Antibody

Novus Biologicals | Catalog # NB100-56654

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all TRAF-3 Primary Antibodies »

Product Specifications

Immunogen

A peptide corresponding to amino acids between 300 and 350 of human TRAF3 was used as immunogen for this antibody.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRAF-3 Antibody

Western Blot: TRAF-3 Antibody [NB100-56654]

Western Blot: TRAF-3 Antibody [NB100-56654]

Western Blot: TRAF-3 Antibody [NB100-56654] - Analysis of TRAF3 in (A) HeLa and (B) NIH 3T3 cell lysate using the TRAF3 antibody at 2 ug/ml.
Immunohistochemistry-Paraffin: TRAF-3 Antibody [NB100-56654]

Immunohistochemistry-Paraffin: TRAF-3 Antibody [NB100-56654]

Immunohistochemistry-Paraffin: TRAF-3 Antibody [NB100-56654] - Analysis of human pancreas using TRAF3 antibody at 1:50.

Applications for TRAF-3 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:100

Western Blot

1 - 3 ug/ml
Application Notes
A 67 kDa band is observed.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS and 0.5% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAF-3

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors. TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.

Long Name

TNF Receptor-Associated Factor 3

Alternate Names

CAP1, CD40bp, CRAF1, LAP1, TRAF3

Entrez Gene IDs

7187 (Human); 22031 (Mouse)

Gene Symbol

TRAF3

UniProt

NP_663778

Additional TRAF-3 Products

Product Documents for TRAF-3 Antibody

Certificate of Analysis

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Product Specific Notices for TRAF-3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for TRAF-3 Antibody

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Protocols

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