Catalog Number: 3497
Alternate Names: Thrombin receptor activator peptide 6
Biological Activity
Peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides.
    Vassallo et al.
    J.Biol.Chem., 1992;267:6081
  2. PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells.
    Kaufmann et al.
    J.Neurooncol., 1999;42:131
  3. Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets.
    Hunter et al.
    J.Biol.Chem., 2009;284:12339

The citations listed below are publications that use Tocris products. Selected citations for TRAP-6 include:

Showing Results 1 - 2 of 2

  1. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci
  2. Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage.
    Authors: Yan Et al.
    Front Bioeng Biotechnol
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