TRAP-6

Tocris Bioscience | Catalog # 3497

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Citations (45)

Product Documents

PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist

Alternative Names

Thrombin receptor activator peptide 6

View all Protease-Activated Receptor Agonists »

Product Description

TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR₁) that acts as a PAR₁ agonist. Stimulates platelet aggregation (EC₅₀ = 0.8 μM), promotes intracellular Ca²⁺ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.

Product Specifications for TRAP-6

Molecular Weight

748.88

Formula

C₃₄H₅₆N₁₀O₉

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

141136-83-6

PubChem ID

9831933

InChI Key

HAGOWCONESKMDW-FRSCJGFNSA-N

SMILES

[H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 45 publications citing the usage of this product.

Kaufmann PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 1999 PMID: 10421070
Hunter Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 2009 PMID: 19261611
Vassallo Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 1992 PMID: 1313429

Product Documents for TRAP-6

Certificate of Analysis

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Product Specific Notices for TRAP-6

For research use only

Citations for TRAP-6

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