Peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1
) that acts as a PAR1
agonist. Stimulates platelet aggregation (EC50
= 0.8 μ
M), promotes intracellular Ca2+
mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro
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Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides.
Vassallo et al.
PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells.
Kaufmann et al.
Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets.
Hunter et al.
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