Biological ActivityTRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides.
Vassallo et al.
PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells.
Kaufmann et al.
Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets.
Hunter et al.
Citations for TRAP-6
The citations listed below are publications that use Tocris products. Selected citations for TRAP-6 include:
5 Citations: Showing 1 - 5
The Low Molecular Weight HP Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways.
Authors: Gockel Et al.
Unfractionated and Low Molecular Weight HP Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells.
Authors: Ponert Et al.
Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34+ cells.
Authors: Dhenge Et al.
Cell Cycle 2017;16:979
Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
Authors: Tripathi Et al.
Invest Ophthalmol Vis Sci 2014;55:3912
Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage.
Authors: Yan Et al.
Front Bioeng Biotechnol 2013;44:1410
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