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TUG 424

Catalog #: 3795 Datasheet / COA / SDS

Discontinued Product

3795 has been discontinued.
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TUG 424 | CAS No. 1082058-99-8 | Free Fatty Acid Receptor Agonists
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Description: FFA1 (GPR40) agonist

Chemical Name: 4-[2-(2-methylphenyl)ethynyl]-benzenepropanoic acid

Purity: ≥99%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Agonist of the free fatty acid receptor FFA1 (GPR40) (EC50 = 32 nM). Enhances glucose-stimulated insulin secretion in INS-1E cells at 100 nM.

Technical Data

M.Wt:
264.32
Formula:
C18H16O2
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1082058-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Southern Denmark.

Background References

  1. A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents.
    Luo J, Swaminath G, Brown S, Zhang J, Guo Q, Chen M, Nguyen K, Tran T, Miao L, Dransfield P, Vimolratana M, Houze J, Wong S, Toteva M, Shan B, Li F, Zhuang R, Lin D
    PLoS ONE, 2012;7(10):e46300.

Product Datasheets

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