TWS 119

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3835/10
TWS 119 | CAS No. 1507095-58-0 | GSK-3 Inhibitors
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Description: GSK-3β inhibitor; induces neuronal differentiation in ESCs

Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenol ditrifluoroacetate

Purity: ≥98%

Product Details
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Biological Activity

Inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).

Technical Data

M.Wt:
546.38
Formula:
C18H14N4O2.2CF3CO2H
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
1507095-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthetic small molecules that control stem cell fate.
    Ding et al.
    Proc.Natl.Acad.Sci., 2003;100:7632
  2. Canonical wnt signaling maintains the quiescent stage of hepatic stellate cells.
    Kordes et al.
    Biochem.Biophys.Res.Comm., 2008;367:116

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