Chemical Name: (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
Biological ActivityInhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain.
Cenedella et al.
Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.
Incardona et al.
The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one.
Liscum and Faust
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I used 2.5-10 ug/ml of U18666A to inhibit the cholesterol efflux in HeLa cells and it worked perfectly as I observed in U18666A treated HeLa cells accumulated cholesterol significantly. I used Filipin staining to image and quantitate the cholesterol levels.