Catalog Number: 0498
Chemical Name: cis-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzamide hydrochloride
Biological Activity
κ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin.
    Sethy and Sage
    Neuropharmacology, 1992;31:111
  2. In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids in the hippocampus.
    Proietti et al.
    Neuropharmacology, 1991;30:637
  3. U-54494A: a unique anticonvulsant related to kappa opioid agonists.
    Voigtlander et al.
    J.Pharmacol.Exp.Ther., 1987;243:542

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