U 83836E
Discontinued Product
Chemical Name: (2R)-2-[[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol dihydrochloride
Purity: ≥98%
Biological Activity
Free radical scavenger and antioxidant; second generation lazaroid that inhibits iron-dependent lipid peroxidation (IC50 = 1.5 μM). Displays neuroprotective activity in a mouse head injury model (MHI) and causes a reduction in cyanide-induced cell death in rat cortical neurons.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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2-(aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia.
Jacobsen et al.
J.Med.Chem., 1992;35:4464 -
Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats.
Altavilla et al.
Br.J.Pharmacol., 1998;124:1293 -
In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia.
Vignes and Hugon
Neurosci.Lett., 2006;407:171
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