Catalog Number: 2745
Chemical Name: 4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid 1,1-dimethylethyl ester
Biological Activity
GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. U-93631 causes rapid decay of γ-aminobutyric acid-induced chloride currents in recombinant rat γ-aminobutyric acid type A receptors.
    Dillon et al.
    Mol.Pharmacol., 1993;44:860
  2. The GABAA receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors.
    Das et al.
    Neuropharmacology, 2003;44:431
  3. [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability.
    Dillon et al.
    J.Pharmacol.Exp.Ther., 1995;272:597
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