Class I HDAC inhibitor (IC50
values are 0.06, 0.1, 0.5 and 1.5 μ
M for HDACs 3, 2, 1 and 8, respectively). Exhibits >6-fold selectivity over other HDACs. Induces accumulation of acetylated histones in HCT116 cells in vitro
. Inhibits proliferation of a range of cancer cell lines. Arrests cells at G1
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Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.
Wang et al.