UFP 803
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Description: Urotensin-II (UT) antagonist
Biological Activity
Urotensin-II (UT) receptor ligand; behaves as a silent antagonist in most in vitro assays and in vivo, but does retain small residual agonist activity under certain conditions in some assays. Competitively antagonizes U-II induced contractions in the rat aorta (pIC50 = 7.46) and prevents plasma extravasation elicited by U-II in mice in vivo.Technical Data
M.Wt:
1061.24
Formula:
C50H64N10O12S2
Sequence:
DXFWXYCV
(Modifications: X-2 = Pen, Trp-4 = D-Trp, X-5 = Dab, Disulfide bridge between 2 - 7)
Solubility:
Soluble in water
Storage:
Desiccate at -20°C
CAS No:
879497-82-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803).
Camarda et al.
Br.J.Pharmacol., 2006;147:92
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