Catalog Number: 0775
Chemical Name: cis-(+)-5-Methoxy-1-methyl-2-(di-N-propylamino)tetralin maleate
Biological Activity
D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay); displays preferential activity at central dopamine autoreceptors. Stimulates a marked acceleration of dopamine synthesis and turnover. Produces locomotor stimulation. Exhibits little or no activity at central noradrenalin and 5-HT receptors. Also D3 partial agonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors.
    Hall and Strange
    Br. J. Pharmacol., 1997;121:731
  2. Novel dopamine receptor agonists and antagonists with preferential action on autoreceptors.
    Johansson et al.
    J.Med.Chem., 1985;28:1049
  3. The preferential dopamine D3 receptor ligand, (+)-UH 232, is a partial agonist.
    Griffon et al.
    Eur.J.Pharmacol., 1995;282:R3
  4. (+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists.
    Svensson et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1986;334:234
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