Catalog Number: 0425
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline
Biological Activity
Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.

Available as part of the α2-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™. Water-soluble Salt also available.

Technical Data
  • M.Wt:
    292.14
  • Formula:
    C11H10BrN5
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    59803-98-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP.
    Andorn et al.
    Life Sci., 1988;43:1805
  2. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
    Chopin et al.
    J.Pharmacol.Exp.Ther., 1999;288:798
  3. Gene trageting - homing in on α2-adrenoceptor-subtype function.
    Macdonald et al.
    TiPS, 1997;18:211
Citations:

The citations listed below are publications that use Tocris products. Selected citations for UK 14,304 include:

3 Citations: Showing 1 - 3
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  1. μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons.
    Authors: Sadeghi Et al.
    J Pharmacol Exp Ther 2015;172:460
  2. MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
    Authors: Tunstall Et al.
    J Neurosci 2011;336:127
  3. The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline.
    Authors: Jasmin Et al.
    Proc Natl Acad Sci U S A 2002;99:1029
Tocris Small Molecules
Description Application Cat# Citations Images  

UK 14,304 tartrate

2466  
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