Selective and competitive urotensin-II (UT) receptor antagonist (pKB
= 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo
. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).
DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7)
Soluble to 2 mg/ml in water
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta.
Patacchini et al.
Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor.
Carotenuto et al.