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Urantide

Catalog #: 5296 Datasheet / COA / SDS

Discontinued Product

5296 has been discontinued.
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Urantide
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Description: Selective and competitive urotensin II receptor antagonist
Alternative Names: [Pen5,DTrp7,Orn8]hU-II(4-11)
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Biological Activity

Urantide is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).

Technical Data

M.Wt:
1075.26
Formula:
C51H66N10O12S2
Sequence:
DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
669089-53-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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