Catalog Number: 5296
Alternate Names: [Pen5,DTrp7,Orn8]hU-II(4-11)
Biological Activity
Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).
Technical Data
  • M.Wt:
    1075.26
  • Formula:
    C51H66N10O12S2
  • Sequence:
    DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    669089-53-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta.
    Patacchini et al.
    Br.J.Pharmacol., 2003;140:1155
  2. Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor.
    Carotenuto et al.
    J.Med.Chem., 2014;57:5965

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