Catalog Number: 1772
Chemical Name: 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Biological Activity
α1-adrenoceptor antagonist and 5-HT1A receptor agonist (pIC50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.
Technical Data
  • M.Wt:
    423.94
  • Formula:
    C20H29N5O3.HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    64887-14-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for α1-adrenoceptor binding sites.
    Gross et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1987;336:597
  2. Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil.
    Kolassa et al.
    Am.J.Cardiol., 1989;64:7D
  3. Pharmacologic profile of urapidil.
    van Zwieten PA
    Am.J.Cardiol., 1989;64:1D

Have you used Urapidil hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information