Urapidil hydrochloride

Key Product Details

Product Description

Urapidil hydrochloride is an α₁-adrenoceptor antagonist and 5-HT_1A receptor agonist (pIC₅₀ values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Product Specifications for Urapidil hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Urapidil hydrochloride

The following data is based on the product molecular weight 423.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.72 mL	23.59 mL	47.18 mL
2.5 mM	0.94 mL	4.72 mL	9.44 mL
5 mM	0.47 mL	2.36 mL	4.72 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kolassa Involvement of brain 5-HT_1A receptors in the hypotensive response to urapidil. Am.J.Cardiol. 1989 PMID: 2569265
• van Zwieten PA Pharmacologic profile of urapidil. Am.J.Cardiol. 1989 PMID: 2569262
• Gross Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT_1A subtype and for α₁-adrenoceptor binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 1987 PMID: 2832770

Product Documents for Urapidil hydrochloride