Urapidil hydrochloride
Chemical Name: 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Purity: ≥99%
Biological Activity
α1-adrenoceptor antagonist and 5-HT1A receptor agonist (pIC50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for α1-adrenoceptor binding sites.
Gross et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1987;336:597 -
Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil.
Kolassa et al.
Am.J.Cardiol., 1989;64:7D -
Pharmacologic profile of urapidil.
van Zwieten PA
Am.J.Cardiol., 1989;64:1D
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