Catalog Number: 1772
Chemical Name: 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Biological Activity
α1-adrenoceptor antagonist and 5-HT1A receptor agonist (pIC50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for α1-adrenoceptor binding sites.
    Gross et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1987;336:597
  2. Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil.
    Kolassa et al.
    Am.J.Cardiol., 1989;64:7D
  3. Pharmacologic profile of urapidil.
    van Zwieten PA
    Am.J.Cardiol., 1989;64:1D
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