Non-competitive MAGL inhibitor. Exhibits selectivity for MAGL over FAAH, diacylglycerol lipase and COX2. Blocks 2-AG hydrolysis in rat brain slices. Enhances stress-induced analgesia in rats.
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An endocannabinoid mechanism for stress-induced analgesia.
Hohmann et al.
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus.
Makara et al.