VE-Cadherin Antibody (012) - Azide and BSA Free

Name: VE-Cadherin Antibody (012) - Azide and BSA Free
Brand: Novus Biologicals
SKU: NBP2-89497
Price: 289 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-89497

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 012 expressed in HEK293

Format

Azide and BSA Free

View all VE-Cadherin Primary Antibodies »

Product Specifications

Immunogen

This antibody was obtained from a rabbit immunized with purified, recombinant Human VE-Cadherin (Accession#: CAA56306.1; Met1-Gln593).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for VE-Cadherin Antibody (012) - Azide and BSA Free

Immunohistochemistry-Paraffin: VE-Cadherin Antibody (012) [NBP2-89497]

Immunohistochemistry-Paraffin: VE-Cadherin Antibody (012) [NBP2-89497] - Staining of human Cad5 in human kidney with rabbit monoclonal antibody (1:500).

Immunohistochemistry-Paraffin: VE-Cadherin Antibody (012) [NBP2-89497]

Immunohistochemistry-Paraffin: VE-Cadherin Antibody (012) [NBP2-89497] - Staining of human Cad5 in human stomach with rabbit monoclonal antibody (1:500).

Applications for VE-Cadherin Antibody (012) - Azide and BSA Free

Application

Recommended Usage

Immunohistochemistry-Paraffin

1:250-1:1000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: VE-Cadherin

VE-cadherin (cadherin-5) is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. VE-cadherin is linked to the actin cytoskeleton through a number of adaptor proteins including a-, â-, and ã-catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cell-cell adhesion. The cytosolic C-terminal Src kinase (Csk) binds via its SH2 domain to the phosphorylated tyrosine 658 site of VE-cadherin. This interaction regulates density dependent cell proliferation. Phosphorylation of tyrosine 658 has also been shown to lead to the uncoupling of p120-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis.

Long Name

Vascular Endothelium Cadherin

Alternate Names

Cadherin-5, CD144, CDH5, VECadherin

Gene Symbol

CDH5

Additional VE-Cadherin Products

Product Documents for VE-Cadherin Antibody (012) - Azide and BSA Free

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Certificate of Analysis

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Product Specific Notices for VE-Cadherin Antibody (012) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.