VER 155008

Catalog # Availability Size / Price Qty
3803/10
3803/50
HSP70 Inhibitors Small Molecule
1 Image
Description: Hsp70 inhibitor

Chemical Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Purity: ≥98%

Product Details
Citations (16)
Reviews (1)

Biological Activity

Novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC50 = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; displays selectivity against Hsp90β (IC50 >200 μM for Hsp90β).

Technical Data

M.Wt:
556.4
Formula:
C25H23Cl2N7O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1134156-31-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for VER 155008

The citations listed below are publications that use Tocris products. Selected citations for VER 155008 include:

16 Citations: Showing 1 - 10

  1. N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione.
    Authors: Gleixner Et al.
    Mol Pharmacol  2017;92:564
  2. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
    Authors: Ganguly Et al.
    J Cell Biol  2017;216:2059
  3. Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer.
    Authors: Cavanaugh Et al.
    Oncotarget  2015;6:39821
  4. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.
    Authors: Thuringer Et al.
    J Cell Biol  2015;6:10267
  5. Sequence-dependent internalization of aggregating peptides.
    Authors: Couceiro Et al.
    Retrovirology  2015;290:242
  6. The regulation of TNFα production after heat and endotoxin stimulation is dependent on Annexin-A1 and HSP70.
    Authors: Nair Et al.
    Cell Stress Chaperones  2015;20:583
  7. Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.
    Authors: O'Regan Et al.
    J Biol Chem  2015;209:349
  8. Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments.
    Authors: Baquero-Perez and Whitehouse
    PLoS Pathog  2015;11:e1005274
  9. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    Oncotarget  2015;11:113
  10. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
    Authors: Truman Et al.
    J Proteomics  2015;112:285

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VER 155008 induces PARP cleavage in U2OS cells
By Anonymous on 03/25/2019
Species: Human

Human osteosarcoma, U2OS, cells were incubated with VER 155008 (1 microM) for 24 h to follow PARP cleavage using Western blot. Hsp70 inhibition with VER 155008 significantly induced PARP cleavage in U2OS cells.


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