VER 155008

Tocris Bioscience | Catalog # 3803

Hsp70 inhibitor
Tocris Bioscience

Key Product Details

Description

Hsp70 inhibitor
View all HSP70 Inhibitors »

Product Description

VER 155008 is a novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC50 = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; displays selectivity against Hsp90β (IC50 >200 μM for Hsp90β).

Product Specifications for VER 155008

Molecular Weight

556.40

Formula

C25H23Cl2N7O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

CAS Number

1134156-31-2

PubChem ID

25195348

InChI Key

ZXGGCBQORXDVTE-UMCMBGNQSA-N

SMILES

NC1=NC=NC2=C1N=C(NCC5=CC=C(Cl)C(Cl)=C5)N2[C@@H]3O[C@H](COCC4=CC=C(C#N)C=C4)[C@@H](O)[C@H]3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.64 100

Preparing Stock Solutions for VER 155008

The following data is based on the product molecular weight 556.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.80 mL 8.99 mL 17.97 mL
5 mM 0.36 mL 1.80 mL 3.59 mL
10 mM 0.18 mL 0.90 mL 1.80 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 56 publications citing the usage of this product.

Product Documents for VER 155008

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VER 155008

For research use only

Customer Reviews for VER 155008 (2)

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  • Potent HSP70 attenuation, alternative for apoptozole.
    Name: Eric Dyne
    Species: Human
    Cell Line/Tissue: Microglia
    Verified Customer | Posted 01/02/2021
    Cytotoxic to microglia at higher dosages (>1uM) observed using a cell viability assay and cell imaging.
    Used this and apoptozole to knock down HSP70 expression. We ended up using Apoptozole for our work but this also worked well. Easy to reconstitute and found to be stable. Confirmed K.D. using qPCR, WB, and IF.
    VER 155008 3803
  • VER 155008 induces PARP cleavage in U2OS cells
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 03/25/2019
    Human osteosarcoma, U2OS, cells were incubated with VER 155008 (1 microM) for 24 h to follow PARP cleavage using Western blot. Hsp70 inhibition with VER 155008 significantly induced PARP cleavage in U2OS cells.
    VER 155008 3803

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