Catalog Number: 3803
Chemical Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
Biological Activity
Novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC50 = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; displays selectivity against Hsp90β (IC50 >200 μM for Hsp90β).
Technical Data
  • M.Wt:
    556.4
  • Formula:
    C25H23Cl2N7O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1134156-31-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
    Massey et al.
    Cancer Chemother.Pharmacol., 2009;66:535
  2. Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
    Williamson et al.
    J.Med.Chem., 2009;52:1510
  3. ATPases as drug targets: insights from heat shock proteins 70 and 90.
    Massey et al.
    J.Med.Chem., 2010;53:7280
  4. Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
    Macias et al.
    J.Med.Chem., 2011;54:4034
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VER 155008 include:

12 Citations: Showing 1 - 10
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  1. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.
    Authors: Thuringer Et al.
    J Cell Biol 2015;6:10267
  2. Sequence-dependent internalization of aggregating peptides.
    Authors: Couceiro Et al.
    Retrovirology 2015;290:242
  3. The regulation of TNFα production after heat and endotoxin stimulation is dependent on Annexin-A1 and HSP70.
    Authors: Nair Et al.
    Cell Stress Chaperones 2015;20:583
  4. Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.
    Authors: O'Regan Et al.
    J Biol Chem 2015;209:349
  5. Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments.
    Authors: Baquero-Perez and Whitehouse
    PLoS Pathog 2015;11:e1005274
  6. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    Oncotarget 2015;11:113
  7. A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.
    Authors: Rodriguez Et al.
    Biochim Biophys Acta 2014;1842:2060
  8. Mutation in integrin-linked kinase (ILK(R211A)) and heat-shock protein 70 comprise a broadly cardioprotective complex.
    Authors: Traister Et al.
    PLoS One 2013;8:e77331
  9. The unfolded protein response selectively targets active smoothened mutants.
    Authors: Marada Et al.
    Mol Cell Biol 2013;33:2375
  10. Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.
    Authors: Wiech Et al.
    PLoS One 2012;7:e51426
  11. The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system.
    Authors: Shorter
    PLoS One 2011;6:e26319
  12. A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.
    Authors: Boroughs Et al.
    J Biol Chem 2011;286:37094
Expand to show all 12 Citations

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