VER 155008

  ( 13 citations )    
Product Datasheet
Catalog Number:3803
Chemical Name:5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
Product Details
Citations (13)
Biological Activity
Novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC50 = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; displays selectivity against Hsp90β (IC50 >200 μM for Hsp90β).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for VER 155008 include:

13 Citations: Showing 1 - 10
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  1. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.
    Authors: Thuringer Et al.
    J Cell Biol  2015;6:10267
  2. Sequence-dependent internalization of aggregating peptides.
    Authors: Couceiro Et al.
    Retrovirology  2015;290:242
  3. The regulation of TNFα production after heat and endotoxin stimulation is dependent on Annexin-A1 and HSP70.
    Authors: Nair Et al.
    Cell Stress Chaperones  2015;20:583
  4. Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.
    Authors: O'Regan Et al.
    J Biol Chem  2015;209:349
  5. Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments.
    Authors: Baquero-Perez and Whitehouse
    PLoS Pathog  2015;11:e1005274
  6. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    Oncotarget  2015;11:113
  7. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
    Authors: Truman Et al.
    J Proteomics  2015;112:285
  8. A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.
    Authors: Rodriguez Et al.
    Biochim Biophys Acta  2014;1842:2060
  9. Mutation in integrin-linked kinase (ILK(R211A)) and heat-shock protein 70 comprise a broadly cardioprotective complex.
    Authors: Traister Et al.
    PLoS One  2013;8:e77331
  10. The unfolded protein response selectively targets active smoothened mutants.
    Authors: Marada Et al.
    Mol Cell Biol  2013;33:2375
  11. Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.
    Authors: Wiech Et al.
    PLoS One  2012;7:e51426
  12. The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system.
    Authors: Shorter
    PLoS One  2011;6:e26319
  13. A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.
    Authors: Boroughs Et al.
    J Biol Chem  2011;286:37094
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