VER 155008

Catalog # Availability Size / Price Qty
VER 155008 | CAS No. 1134156-31-2 | HSP70 Inhibitors
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Description: Hsp70 inhibitor

Chemical Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Purity: ≥98%

Product Details
Citations (18)

Biological Activity

VER 155008 is a novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC50 = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; displays selectivity against Hsp90β (IC50 >200 μM for Hsp90β).

Technical Data

Soluble to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for VER 155008

The citations listed below are publications that use Tocris products. Selected citations for VER 155008 include:

18 Citations: Showing 1 - 10

  1. Hsp70 and DNAJA2 limit CFTR levels through degradation.
    Authors: Chiaw Et al.
    PLoS One  2019;14:e0220984
  2. Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.
    Authors: Rinaldi Et al.
    Nat Commun  2019;10:2572
  3. N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione.
    Authors: Gleixner Et al.
    Mol Pharmacol  2017;92:564
  4. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
    Authors: Ganguly Et al.
    J Cell Biol  2017;216:2059
  5. Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer.
    Authors: Cavanaugh Et al.
    Oncotarget  2015;6:39821
  6. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.
    Authors: Thuringer Et al.
    J Cell Biol  2015;6:10267
  7. Sequence-dependent internalization of aggregating peptides.
    Authors: Couceiro Et al.
    Retrovirology  2015;290:242
  8. The regulation of TNFα production after heat and endotoxin stimulation is dependent on Annexin-A1 and HSP70.
    Authors: Nair Et al.
    Cell Stress Chaperones  2015;20:583
  9. Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.
    Authors: O'Regan Et al.
    J Biol Chem  2015;209:349
  10. Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments.
    Authors: Baquero-Perez and Whitehouse
    PLoS Pathog  2015;11:e1005274


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