Viperin Antibody

Novus Biologicals | Catalog # NBP2-03971

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bovine, Canine, Chicken, Chinese Hamster, Equine, Primate, Rabbit

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
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Product Specifications

Immunogen

A portion of amino acids 165-215 of human viperin was used as the immunogen for this antibody.

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in white-cheeked gibbon, chinese hamster, common chimpanzee, new world monkey, panda, african bush elephant and orangutan, 95% in horse, wild turkey, opossum, platypus, 89% in western clawed frog, rabbit, zebra finch, chicken, 79% in carolina anole, and 63% homologous in zebrafish and sablefish.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Viperin Antibody

Western Blot: Viperin Antibody [NBP2-03971]

Western Blot: Viperin Antibody [NBP2-03971]

Western Blot: Viperin Antibody [NBP2-03971] - Analysis of viperin using viperin polyclonal antibody. Human brain lysate in the absence (1) and presence (2) of immunizing peptide, mouse brain (3) and rat brain (4) lysate probed with viperin antibody at 3 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: Viperin Antibody [NBP2-03971]

Immunohistochemistry-Paraffin: Viperin Antibody [NBP2-03971]

Immunohistochemistry-Paraffin: Viperin Antibody [NBP2-03971] - Analysis of viperin using viperin polyclonal antibody. Human rectum tissue probed with viperin antibody at 5 ug/ml.

Applications for Viperin Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml

Western Blot

3-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Viperin

Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies. Additionally, viperin antibodies provide useful information for analysis of specific cell types responsive to interferon making it valuable for phenotyping studies complementing mechanism of action analysis.

Alternate Names

2510004L01Rik, cig33, cig5, Cytomegalovirus-induced gene 5 protein, interferon-inducible, radical S-adenosyl methionine domain containing 2, radical S-adenosyl methionine domain-containing protein 2, vig1, VIPERIN, Virus inhibitory protein, endoplasmic reticulum-associated

Gene Symbol

RSAD2

UniProt

NP_542388.2 (Human)

Additional Viperin Products

Product Documents for Viperin Antibody

Certificate of Analysis

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Product Specific Notices for Viperin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Viperin Antibody

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Protocols

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