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Virodhamine

Catalog #: 1569 Datasheet / COA / SDS

Discontinued Product

1569 has been discontinued.
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Virodhamine | CAS No. 287937-12-6 | Non-selective Cannabinoid Receptor Agonists
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Description: GPR55 and CB2 agonist. CB1 partial agonist/antagonist
Alternative Names: O-Arachidonyl ethanolamine

Chemical Name: O-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenoate

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Biological Activity

Endogenous cannabinoid receptor mixed agonist/antagonist found in higher concentrations peripherally than anandamide. Full agonist at GPR55 and CB2 and partial agonist/antagonist at CB1 (EC50 values are 12, 381 and 2920 nM at GPR55, CB2 and CB1 receptors respectively). Induces hypothermia in vivo.

Technical Data

M.Wt:
347.54
Formula:
C22H37NO2
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Storage:
Desiccate at -20°C
CAS No:
287937-12-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor.
    Porter et al.
    J.Pharmacol.Exp.Ther., 2002;301:1020
  3. The orphan receptor GPR55 is a novel cannabinoid receptor.
    Ryberg et al.
    Br.J.Pharmacol., 2007;152:1092
  4. Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor.
    Porter et al.
    J.Pharmacol.Exp.Ther., 2002;301:1020
  5. Further characterization of the novel endocannabinoid virodhamine.
    Sauer et al.
    2002 Symposium on the Cannabinoids, International, 2002;

Product Datasheets

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