Catalog Number: 0532
Chemical Name: Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
Biological Activity
Stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Increases the protective effect of atropine against organophosphate poisoning.
Technical Data
  • M.Wt:
    708.53
  • Formula:
    C32H44Br2N4O4
  • Solubility:
    Soluble to 10 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    21093-51-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Allosteric stabilisation of [3H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication.
    Jepsen et al.
    Pharmacol.Toxicol., 1988;63:163
  2. Antimuscarinic action of an alkane-bis ammonium compound alone and in combination with (+)-bensetimide.
    Mitchelson
    Eur.J.Pharmacol., 1975;33:237
  3. Equipotent allosteric effect of W84 on [3H]-NMS binding to cardiac muscarinic receptors from guinea-pig, rat and pig.
    Mohr et al.
    Pharmacol.Toxicol., 1992;70:198

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