Catalog Number: 2799
Alternate Names: ω-Aga-IV A
Biological Activity
Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge between 4 - 20, 12 - 25, 19 - 36, 27 - 34)

  • Solubility:
    Soluble in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Calcium channels coupled to glutamate release identified by ω-Aga-IVA.
    Turner et al.
    Science, 1992;258:310
  2. Protease treatment of cerebellar purkinje cells renders ω-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by ω-conotoxin GVIA.
    Tringham et al.
    J.Pharmacol.Exp.Ther., 2008;324:806
  3. Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.
    Bourinet et al.
    Nat.Neurosci., 1999;2:407
  4. P-type calcium channels blocked by the spider toxin ω-Aga-IVA.
    Mintz et al.
    Nature, 1992;355:827

The citations listed below are publications that use Tocris products. Selected citations for ω-Agatoxin IVA include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature 2017;543:391
  2. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
    Authors: Medrihan Et al.
    Nature 2013;4:1512
  3. The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period.
    Authors: Jiang Et al.
    Neuron 2010;66:248
  4. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci 2010;13:958

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