Biological Activityω-Agatoxin IVA is a selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.
(Modifications: Disulfide bridge between 4 - 20, 12 - 25, 19 - 36, 27 - 34)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
P-type calcium channels blocked by the spider toxin ω-Aga-IVA.
Mintz et al.
Calcium channels coupled to glutamate release identified by ω-Aga-IVA.
Turner et al.
Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.
Bourinet et al.
Protease treatment of cerebellar purkinje cells renders ω-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by ω-conotoxin GVIA.
Tringham et al.
Citations for ω-Agatoxin IVA
The citations listed below are publications that use Tocris products. Selected citations for ω-Agatoxin IVA include:
6 Citations: Showing 1 - 6
Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth.
Authors: Kim Et al.
Sci Rep 2018;8:7566
Molecular basis of ancestral vertebrate electroreception.
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
Authors: Medrihan Et al.
The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period.
Authors: Jiang Et al.
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Authors: Higley and Sabatini
Nat Neurosci 2010;13:958
Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala.
Authors: Azad Et al.
Learn Mem 2008;15:143
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Reviews for ω-Agatoxin IVA
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The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.