Catalog Number: 2802
Alternate Names: Agatoxin IVB
Biological Activity
Selective blocker of CaV2.1 P/Q-type calcium channels.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge between 4 - 20, 12 - 25, 19 - 36, 27 - 34)

  • Solubility:
    Soluble in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel type of calcium channel sensitive to ω-agatoxin-TK in cultured rat cerebral cortical neurons.
    Teramoto et al.
    Brain Res., 1997;756:225
  2. High-affinity inhibition of glutamate release from corticostriatal synapses by ω-agatoxin TK.
    Barral et al.
    Eur.J.Pharmacol., 2001;430:167
  3. A novel peptide from funnel web spider venom, ω-Aga-TK, selectively blocks P-type calcium channels.
    Teramoto et al.
    Biochem.Biophys.Res.Comms., 1993;196:134

The citations listed below are publications that use Tocris products. Selected citations for ω-Agatoxin TK include:

Showing Results 1 - 4 of 4

  1. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
  2. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
    Authors: Fakira Et al.
    J Neurosci
  3. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
    Authors: Grubb and Burrone
    Mol Cell Neurosci
  4. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem
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