Biological Activityω-Agatoxin TK is a selective blocker of CaV2.1 P/Q-type calcium channels.
(Modifications: Disulfide bridge between 4 - 20, 12 - 25, 19 - 36, 27 - 34)
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel type of calcium channel sensitive to ω-agatoxin-TK in cultured rat cerebral cortical neurons.
Teramoto et al.
Brain Res., 1997;756:225
High-affinity inhibition of glutamate release from corticostriatal synapses by ω-agatoxin TK.
Barral et al.
A novel peptide from funnel web spider venom, ω-Aga-TK, selectively blocks P-type calcium channels.
Teramoto et al.
Citations for ω-Agatoxin TK
The citations listed below are publications that use Tocris products. Selected citations for ω-Agatoxin TK include:
5 Citations: Showing 1 - 5
Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Authors: Cramer Et al.
Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
Authors: Fakira Et al.
J Neurosci 2012;51:22
Concurrent imaging of synaptic vesicle recycling and calcium dynamics.
Authors: Li Et al.
Front Mol Neurosci 2011;4:34
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
Authors: Grubb and Burrone
Mol Cell Neurosci 2010;465:1070
Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
Authors: Maier Et al.
J Biol Chem 2010;285:35606
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