ω-Conotoxin GVIA

  ( 15 citations )    
Product Datasheet
Catalog Number:1085
Chemical Name:
Product Details
Citations (15)
Reviews
Biological Activity
Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.
Technical Data
  • M.Wt:
    3037
  • Formula:
    C120H182N38O43S6
  • Sequence:
    CKSXGSSCSXTSYNCCRSCNXYTKRCY

    (Modifications: X = Hyp, Disulfide bridge between 1 - 16, 8 - 19, 15 - 26, Tyr-27 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    106375-28-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ω-Conotoxin GVIA include:

15 Citations: Showing 1 - 10
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  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391
  2. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
    Authors: Cassilly Et al.
    Front Cell Neurosci  2016;11:e0154932
  3. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.
    Authors: Perissinotti Et al.
    Proc Natl Acad Sci U S A  2015;8:444
  4. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Addict Biol  2014;350:290
  5. Presynaptic calcium channel inhibition underlies CB1� cannabinoid receptor-mediated suppression of GABA release.
    Authors: Szabó Et al.
    PLoS One  2014;34:7958
  6. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
    Authors: Mahler Et al.
    J Neurosci  2014;19:49
  7. Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels.
    Authors: Schuwald Et al.
    J Neurosci  2013;8:e59998
  8. Comparative functional expression of nAChR subtypes in rodent DRG neurons.
    Authors: Smith Et al.
    Front Cell Neurosci  2013;7:225
  9. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
    Authors: Medrihan Et al.
    Nature  2013;4:1512
  10. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice.
    Authors: Izzo Et al.
    Br J Pharmacol  2012;166:1444
  11. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
    Authors: Grubb and Burrone
    J Pharmacol Exp Ther  2010;465:1070
  12. Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
    Authors: Kim and Alger
    Nat Neurosci  2010;13:592
  13. Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses.
    Authors: Chang
    J Neurophysiol  2010;103:392
  14. Secretin as a neurohypophysial factor regulating body water homeostasis.
    Authors: Chu Et al.
    PLoS One  2009;106:15961
  15. Molecular profiling reveals synaptic release machinery in Merkel cells.
    Authors: Haeberle Et al.
    Proc Natl Acad Sci U S A  2004;101:14503
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