Biological Activityω-Conotoxin GVIA is a peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.
(Modifications: X = Hyp, Disulfide bridges: 1-16, 8-19, 15-26, Tyr-27 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression.
Connelly et al.
Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels.
Sato et al.
Multiple types of neuronal calcium channels and their selective modulation.
Tsien et al.
Prolonged cardiovascular effects of the N-type Ca2+ channel antagonist ω-conotoxin GVIA in conscious rabbits.
Wright and Angu
Citations for ω-Conotoxin GVIA
The citations listed below are publications that use Tocris products. Selected citations for ω-Conotoxin GVIA include:
15 Citations: Showing 1 - 10
Molecular basis of ancestral vertebrate electroreception.
SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
Authors: Cassilly Et al.
Front Cell Neurosci 2016;11:e0154932
Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.
Authors: Perissinotti Et al.
Proc Natl Acad Sci U S A 2015;8:444
σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
Authors: Pan Et al.
Addict Biol 2014;350:290
Presynaptic calcium channel inhibition underlies CB1� cannabinoid receptor-mediated suppression of GABA release.
Authors: Szabó Et al.
PLoS One 2014;34:7958
Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Authors: Mahler Et al.
J Neurosci 2014;19:49
Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels.
Authors: Schuwald Et al.
J Neurosci 2013;8:e59998
Comparative functional expression of nAChR subtypes in rodent DRG neurons.
Authors: Smith Et al.
Front Cell Neurosci 2013;7:225
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
Authors: Medrihan Et al.
Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice.
Authors: Izzo Et al.
Br J Pharmacol 2012;166:1444
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
Authors: Grubb and Burrone
J Pharmacol Exp Ther 2010;465:1070
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Authors: Kim and Alger
Nat Neurosci 2010;13:592
Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses.
J Neurophysiol 2010;103:392
Secr. as a neurohypophysial factor regulating body water homeostasis.
Authors: Chu Et al.
PLoS One 2009;106:15961
Molecular profiling reveals synaptic release machinery in Merkel cells.
Authors: Haeberle Et al.
Proc Natl Acad Sci U S A 2004;101:14503
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