Catalog Number: 1085
Biological Activity
Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: X = Hyp, Disulfide bridge between 1 - 16, 8 - 19, 15 - 26, Tyr-27 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression.
    Connelly et al.
    Eur.J.Pharmacol., 2011;667:160
  2. Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels.
    Sato et al.
    Biochem.Biophys.Res.Comm., 1993;194:1292
  3. Multiple types of neuronal calcium channels and their selective modulation.
    Tsien et al.
    TiNS, 1988;11:431
  4. Prolonged cardiovascular effects of the N-type Ca2+ channel antagonist ω-conotoxin GVIA in conscious rabbits.
    Wright and Angu
    J.Cardiovasc.Pharmacol., 1997;30:392

The citations listed below are publications that use Tocris products. Selected citations for ω-Conotoxin GVIA include:

Showing Results 1 - 10 of 11

  1. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
    Authors: Cassilly Et al.
    Front Cell Neurosci
  2. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.
    Authors: Perissinotti Et al.
    Proc Natl Acad Sci U S A
  3. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Addict Biol
  4. Presynaptic calcium channel inhibition underlies CB1� cannabinoid receptor-mediated suppression of GABA release.
    Authors: Szabó Et al.
    PLoS One
  5. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
    Authors: Mahler Et al.
    J Neurosci
  6. Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels.
    Authors: Schuwald Et al.
    J Neurosci
  7. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
    Authors: Medrihan Et al.
  8. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
    Authors: Grubb and Burrone
    J Pharmacol Exp Ther
  9. Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
    Authors: Kim and Alger
    Nat Neurosci
  10. Secretin as a neurohypophysial factor regulating body water homeostasis.
    Authors: Chu Et al.
    PLoS One
  11. Molecular profiling reveals synaptic release machinery in Merkel cells.
    Authors: Haeberle Et al.
    Proc Natl Acad Sci U S A
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