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ω-Conotoxin MVIIC

Catalog #: 1084
11 Citations Datasheet / COA / SDS

Discontinued Product

1084 has been discontinued.
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ω-Conotoxin MVIIC
1 Image
Description: CaV2.x blocker
Product Details
Citations (11)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

ω-Conotoxin MVIIC is a peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Technical Data

M.Wt:
2749
Formula:
C106H178N40O32S7
Sequence:
CKGKGAPCRKTMYDCCSGSCGRRGKC

(Modifications: Disulfide bridges: 1-16, 8-20, 15-26, Cys-26 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
147794-23-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Utah.

Product Datasheets

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for ω-Conotoxin MVIIC

The citations listed below are publications that use Tocris products. Selected citations for ω-Conotoxin MVIIC include:

11 Citations: Showing 1 - 10

  1. STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry.
    Authors: Pascual-Caro Et al.
    J Mol Med (Berl)  2018;96:1061
  2. Methyl-β-Cyclodextrin Impairs the Phosphorylation of the β2 Subunit of L-Type Calcium Channels and Cytosolic Calcium Homeostasis in Mature Cerebellar Granule Neurons.
    Authors: Fortalezas Et al.
    Int J Mol Sci  2018;19
  3. Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents.
    Authors: Luca Et al.
    Neuron  2017;95:63
  4. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
    Authors: Hashiguchi
    PLoS One  2017;12(9):e0184261
  5. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent.
    Authors: Hanlon Et al.
    Breast Cancer (Dove Med Press)  2016;8:59
  6. Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds.
    Authors: Schöbel Et al.
    Chem Senses  2014;39:471
  7. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    PLoS One  2014;350:290
  8. Comparative functional expression of nAChR subtypes in rodent DRG neurons.
    Authors: Smith Et al.
    Front Cell Neurosci  2013;7:225
  9. Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses.
    Authors: Schöbel Et al.
    PLoS One  2012;7:e48005
  10. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem  2010;285:35606
  11. Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells.
    Authors: Haeberle Et al.
    Nat Commun  2008;3:e1750

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