WB 4101 hydrochloride
Discontinued Product
Chemical Name: 2-(2,6-Dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride
Purity: ≥99%
Biological Activity
α1A-adrenergic selective antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes.
Green et al.
J.Med.Chem., 1969;12:326 -
α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Heible et al.
J.Med.Chem., 1995;38:3415 -
Characterisation of α1-adrenergic receptor subtypes in rat brain: a re-evaluation of 3H-WB 4101 and 3H-prazosin binding.
Morrow and Creese
Mol.Pharmacol., 1986;29:321
Product Datasheets
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Citations for WB 4101 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for WB 4101 hydrochloride include:
5 Citations: Showing 1 - 5
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Identification of WB4101, an α1-Adrenoceptor Antagonist, as a Sodium Channel Blocker.
Authors: Li Et al.
Mol Pharmacol 2018;94:896
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Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats.
Authors: Alves Et al.
Circ Res 2014;9:e83900
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Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear.
Authors: Hott Et al.
Br J Pharmacol 2012;167:207
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Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats.
Authors: Crestani Et al.
Br J Pharmacol 2008;153:583
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Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel.
Authors: O-Uchi Et al.
J Endocrinol 2008;102:1378
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