Catalog Number: 2327
Alternate Names: (S)-(-)-WIN 55,212
Chemical Name: [(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone monomethanesulfonate
Biological Activity
Novel, low potency CB2 receptor silent antagonist and CB1 receptor partial inverse agonist. Competitively antagonizes effects of CP 55,940 (pA2 = 6.1) and SR 144528 (pEC50 = 5.3) at CB2 receptors and acts as a partial inverse agonist at CB1 receptors (pIC50 = 5.5). Displays modest activity at human melatonin MT1 and muscarinic M4 receptors, but is selective over several other GPCRs.

R-enantiomer also available.

Technical Data
  • M.Wt:
    522.61
  • Formula:
    C27H26N2O3.CH3SO3H
  • Solubility:
    Soluble to 100 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    131543-25-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
    Savinainen et al.
    Br.J.Pharmacol., 2005;145:636
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WIN 55,212-3 mesylate include:

1 Citations: Showing 1 - 1

  1. Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release.
    Authors: Mereu Et al.
    Proc Natl Acad Sci U S A 2003;100:4915
Tocris Small Molecules
Description Application Cat# Citations Images  

WIN 55,212-2 mesylate

1038 62  
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