XAV 939

Tocris Bioscience | Catalog # 3748

GMP Version Available: TB3748-GMP
GMP
Potent tankyrase inhibitor
Tocris Bioscience

Key Product Details

Description

Potent tankyrase inhibitor

Alternative Names

XAV939 Wnt Signaling Inhibitor
View all Tankyrase Inhibitors »

Product Description

XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols (see below).

XAV 939 synthesized to cGMP guidelines also available.

For more information about how XAV 939 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of XAV939 is reviewed on the chemical probes website.

Product Specifications for XAV 939

Molecular Weight

312.31

Formula

C14H11F3N2OS

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

CAS Number

284028-89-3

PubChem ID

2726824

InChI Key

KLGQSVMIPOVQAX-UHFFFAOYSA-N

SMILES

OC1=C(CSCC2)C2=NC(C3=CC=C(C(F)(F)F)C=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.25 20

Preparing Stock Solutions for XAV 939

The following data is based on the product molecular weight 312.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 16.01 mL 80.05 mL 160.10 mL
1 mM 3.20 mL 16.01 mL 32.02 mL
2 mM 1.60 mL 8.00 mL 16.01 mL
10 mM 0.32 mL 1.60 mL 3.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 358 publications citing the usage of this product.

Product Documents for XAV 939

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for XAV 939

For research use only

Customer Reviews for XAV 939 (1)

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  • Wnt signaling inhibitor
    Name: Kishor Pant
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HuCCt1 and H69
    Verified Customer | Posted 05/22/2019
    XAV 393 inhibits the B-catenin expression in cancer cells in-vitro at 500nM.
    XAV 939 3748

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