Catalog Number: 3748
Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Biological Activity
Potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tankyrase inhibition stabilizes axin and antagonizes wnt signalling.
    Huang et al.
    Nature, 2009;461:614
  2. Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling.
    Wang et al.
    ACS Chem. Biol., 2010;6:192
  3. Inhibiting wnt signaling.
    Sci.Signal., 2009;91

The citations listed below are publications that use Tocris products. Selected citations for XAV 939 include:

Showing Results 1 - 10 of 15

  1. Downregulation of Wnt signaling by sonic hedgehog activation promotes repopulation of human tumor cell lines.
    Authors: Ma Et al.
    J Cell Mol Med
  2. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
    Authors: Jain Et al.
    Nat Commun
  3. A balance of positive and negative regulators determines the pace of the segmentation clock.
    Authors: Wiedermann Et al.
  4. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
  5. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.
    Authors: Szabo Et al.
    Dis Model Mech
  6. Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts.
    Authors: Gerbin Et al.
    PLoS One
  7. Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes.
    Authors: Palpant Et al.
    PLoS One
  8. Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells.
    Authors: Wang Et al.
    Genome Biol
  9. Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.
    Authors: Jiang Et al.
    ASN Neuro
  10. WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs.
    Authors: Jiang Et al.
    Stem Cell Reports
  11. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.
    Authors: Palpant Et al.
  12. BMP-mediated specification of the erythroid lineage suppresses endothelial development in blood island precursors.
    Authors: Myers and Krieg
  13. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation.
    Authors: Wu Et al.
    J Neurosci
  14. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.
    Authors: Fancy Et al.
    Nat Neurosci
  15. NKG2D receptor regulates human effector T-cell cytokine production.
    Authors: Barber and Sentman
    Cell Res
Expand to show all
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