XAV 939

  ( 27 citations )    
Product Datasheet
Catalog Number:3748
Chemical Name:3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Product Details
Citations (27)
Supplemental Products
Biological Activity
Potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of XAV939 is reviewed on the chemical probes website.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for XAV 939 include:

27 Citations: Showing 1 - 10
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  1. Heparanase attenuates axon degeneration following sciatic nerve transection.
    Authors: Whitehead
    Sci Rep  2018;8(1):5219
  2. β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.
    Authors: Koopmans Et al.
    Front Immunol  2017;8:1086
  3. Specification of murine ground state pluripotent stem cells to regional neuronal populations.
    Authors: Alsanie
    Sci Rep  2017;7(1):16001
  4. Degree of tissue differentiation dictates susceptibility to BRAF-driven colorectal cancer.
    Authors: Tong
    Cell Rep  2017;21(13):3833
  5. Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation.
    Authors: Al-Dhfyan
    Mol Cancer  2017;16:14
  6. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
    Authors: Young
    Proc Natl Acad Sci U S A.  2017;114(28):E5599
  7. Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using humanpluripotent stem cells
    Authors: Palpant Et al.
    Nature Protocols  2016;12:15
  8. Downregulation of Wnt signaling by sonic hedgehog activation promotes repopulation of human tumor cell lines.
    Authors: Ma Et al.
    J Cell Mol Med  2015;8:385
  9. β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.
    Authors: Hong Et al.
    Cancer Res  2015;75:656
  10. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
    Authors: Jain Et al.
    Nat Commun  2015;6:6727
  11. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
    Authors: Mallinger Et al.
    J Med Chem  2015;58:1717
  12. A balance of positive and negative regulators determines the pace of the segmentation clock.
    Authors: Wiedermann Et al.
    Elife  2015;4
  13. Neural cells play an inhibitory role in pancreatic differentiation of pluripotent stem cells.
    Authors: Nakashima Et al.
    Genes Cells  2015;20:1028
  14. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
    Blood  2015;19:210
  15. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.
    Authors: Szabo Et al.
    Dis Model Mech  2015;16:126
  16. Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts.
    Authors: Gerbin Et al.
    PLoS One  2015;10:e0131446
  17. Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes.
    Authors: Palpant Et al.
    PLoS One  2015;10:e0126259
  18. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway.
    Authors: Nishiya Et al.
    Chem Biol  2014;21:530
  19. Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells.
    Authors: Wang Et al.
    Genome Biol  2013;8:e72846
  20. Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.
    Authors: Jiang Et al.
    ASN Neuro  2013;23:122
  21. WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs.
    Authors: Jiang Et al.
    Stem Cell Reports  2013;1:46
  22. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.
    Authors: Palpant Et al.
    Development  2013;140:3799
  23. BMP-mediated specification of the erythroid lineage suppresses endothelial development in blood island precursors.
    Authors: Myers and Krieg
    Blood  2013;122:3929
  24. WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis.
    Authors: Yang Et al.
    EMBO Mol Med  2012;4:1294
  25. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation.
    Authors: Wu Et al.
    J Neurosci  2012;32:6651
  26. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.
    Authors: Fancy Et al.
    Nat Neurosci  2011;14:1009
  27. NKG2D receptor regulates human effector T-cell cytokine production.
    Authors: Barber and Sentman
    Cell Res  2011;117:6571
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