Potent tankyrase (TNKS) inhibitor (IC50
values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β
-catenin degradation and stabilization of axin. Inhibits proliferation of the β
-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.
Soluble to 20 mM in DMSO
Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Tankyrase inhibition stabilizes axin and antagonizes wnt signalling.
Huang et al.
Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling.
Wang et al.
ACS Chem. Biol., 2010;6:192
Inhibiting wnt signaling.
The citations listed below are publications that use Tocris products. Selected citations for XAV 939 include:
Showing Results 1 - 10 of 15