Potent and selective blocker of KV
7 (KCNQ) voltage-gated potassium channels. Blocks KV
7.2+7.3 (KCNQ2+3) / M-currents (IC50
= 0.6 - 0.98 μ
M) and KV
7.1 (KCNQ1) homomeric channels (IC50
= 0.75 μ
M) but is less potent against KV
7.1/minK channels (IC50
= 11.1 μ
M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo
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All Tocris products are intended for laboratory research use only.
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.
Zaczek et al.
Molecular basis for differential sensitivity of KCNQ and IKs channels to the cognitive enhancer XE991.
Wang et al.
KCNQ/M currents in sensory neurons: significance for pain therapy.
Passmore et al.
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
Wang et al.
The citations listed below are publications that use Tocris products. Selected citations for XE 991 dihydrochloride include:
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