XE 991 dihydrochloride

Tocris Bioscience | Catalog # 2000

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents
Tocris Bioscience

Key Product Details

Description

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents
View all Voltage-gated Potassium Channel Blockers »

Product Description

XE 991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. Blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Product Specifications for XE 991 dihydrochloride

Molecular Weight

449.37

Formula

C26H20N2O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

CAS Number

122955-13-9

PubChem ID

45073462

InChI Key

WOGWMARIFDNZON-UHFFFAOYSA-N

SMILES

Cl.Cl.O=C1C2=C(C=CC=C2)C(CC2=CC=NC=C2)(CC2=CC=NC=C2)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.94 100

Preparing Stock Solutions for XE 991 dihydrochloride

The following data is based on the product molecular weight 449.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.13 mL 22.25 mL
5 mM 0.45 mL 2.23 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 1150 publications citing the usage of this product.

Product Documents for XE 991 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for XE 991 dihydrochloride

For research use only

Citations for XE 991 dihydrochloride

Customer Reviews for XE 991 dihydrochloride (1)

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  • XE 991 worked ideally in lab coditions, produced reproducible data
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 10/22/2018
    XE 991 is a potent Kv7 channel blocker.My study focused on to finding out whether it shows the same blocking effect on Kv11.1 channels. The product worked ideally in lab coditions, produced reproducible data. Would purchase again.
    XE 991 dihydrochloride 2000

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