C-Terminal fragment of xenin, a neurotensin-like peptide; modulates pancreatic insulin and glucagon secretion/effects. Stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50
= 0.16 nM). Also potentiates arginine- and carbachol-induced glucagon secretion in a somatostatin-independent manner.
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Xenopsin-related peptide generated in avian gastric extracts.
Carraway et al.
Metabolism and potency of xenin and of its reduced hexapseudopeptide ψ fragment in dog.
Feurle et al.
Life Sci., 2003;74:697
Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas.
Silvestre et al.