Xenin 8
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Description: Neurotensin-like peptide; potentiates insulin and glucagon secretion
Alternative Names: Xenopsin-related peptide 1, XP-1
Biological Activity
Xenin 8 is a C-Terminal fragment of xenin, a neurotensin-like peptide; modulates pancreatic insulin and glucagon secretion/effects. Stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50 = 0.16 nM). Also potentiates arginine- and carbachol-induced glucagon secretion in a somatostatin-independent manner.Technical Data
M.Wt:
1046.28
Formula:
C51H79N15O9
Sequence:
HPKRPWIL
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
117442-28-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Xenopsin-related peptide generated in avian gastric extracts.
Carraway et al.
Regul.Pept., 1988;22:303 -
Metabolism and potency of xenin and of its reduced hexapseudopeptide ψ fragment in dog.
Feurle et al.
Life Sci., 2003;74:697 -
Stimulatory effect of xenin-8 on Ins and glucagon secretion in the perfused rat pancreas.
Silvestre et al.
Regul.Pept., 2003;115:25
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