Ras-Net (Elk-3) pathway inhibitor (IC50
= 10 - 20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2
-M cell cycle arrest, suppresses growth of multiple cell types (IC50
~ 2 nM), inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro
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Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.
Wasylyk et al.
Cancer Res., 2008;68:1275