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XRP44X

Catalog #: 3101 Datasheet / COA / SDS

Discontinued Product

3101 has been discontinued.
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XRP44X | CAS No. 729605-21-4 | Ras GTPase Inhibitors
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Description: Ras-Net (Elk-3) pathway inhibitor; also microtubule depolymerization agent and angiogenesis inhibitor

Chemical Name: 1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine

Purity: ≥99%

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Biological Activity

Ras-Net (Elk-3) pathway inhibitor (IC50 = 10 - 20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2-M cell cycle arrest, suppresses growth of multiple cell types (IC50 ~ 2 nM), inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro.

Technical Data

M.Wt:
380.87
Formula:
C21H21ClN4O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
729605-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.
    Wasylyk et al.
    Cancer Res., 2008;68:1275

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