Home / Focal Adhesion Kinase Inhibitors / Y 11

Y 11

Catalog #: 4498
4 Citations Datasheet / COA / SDS

Discontinued Product

4498 has been discontinued.
View all Focal Adhesion Kinase Inhibitors products.
Y 11 | CAS No. 1086639-59-9 | Focal Adhesion Kinase Inhibitors
1 Image
Description: Potent and selective FAK inhibitor

Chemical Name: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Y 11 is a potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.

Technical Data

M.Wt:
265.15
Formula:
C8H17N4OBr
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
1086639-59-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Y 11

The citations listed below are publications that use Tocris products. Selected citations for Y 11 include:

4 Citations: Showing 1 - 4

  1. Trapping, tagging and tracking: Tools for the study of proteins during early development of the sea urchin.
    Authors: Gary Et al.
    Methods Cell Biol  2019;151:283-304
  2. Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
    Authors: Keasey Et al.
    J Cell Sci  2018;131
  3. Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.
    Authors: Brown Et al.
    Mol Cancer Res  2015;13:78
  4. Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields.
    Authors: Robinson Et al.
    PLoS One  2015;10:e0143798

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Y 11

There are currently no reviews for this product. Be the first to review Y 11 and earn rewards!

Have you used Y 11?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.