Catalog Number: 4498
Chemical Name: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide
Biological Activity
Potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
Technical Data
  • M.Wt:
    265.15
  • Formula:
    C8H17N4OBr
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    1086639-59-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonoge
    Golubovskaya et al.
    Carcinogenesis, 2012;
  2. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth.
    Golubovskaya et al.
    J.Med.Chem., 2008;51:7405
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Y 11 include:

1 Citations: Showing 1 - 1

  1. Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.
    Authors: Brown Et al.
    Mol Cancer Res 2015;13:78

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