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Y 11

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Y 11 | CAS No. 1086639-59-9 | Focal Adhesion Kinase Inhibitors
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Description: Potent and selective FAK inhibitor

Chemical Name: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide

Product Details
Citations (3)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.

Technical Data

M.Wt:
265.15
Formula:
C8H17N4OBr
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
1086639-59-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Y 11

The citations listed below are publications that use Tocris products. Selected citations for Y 11 include:

3 Citations: Showing 1 - 3

  1. Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
    Authors: Keasey Et al.
    J Cell Sci  2018;131
  2. Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.
    Authors: Brown Et al.
    Mol Cancer Res  2015;13:78
  3. Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields.
    Authors: Robinson Et al.
    PLoS One  2015;10:e0143798

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Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments
By Anonymous on 03/24/2020
Application: Species: Rat

Pharmacological antagonists of FAK for 4 h before RNA or protein isolation FAK antagonists were Y11

PMID: 29222114
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