Chemical Name: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[220.127.116.11,7]decane bromide
Biological ActivityPotent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [18.104.22.168,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonoge
Golubovskaya et al.
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth.
Golubovskaya et al.
Citations for Y 11
The citations listed below are publications that use Tocris products. Selected citations for Y 11 include:
3 Citations: Showing 1 - 3
Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Authors: Keasey Et al.
J Cell Sci 2018;131
Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.
Authors: Brown Et al.
Mol Cancer Res 2015;13:78
Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields.
Authors: Robinson Et al.
PLoS One 2015;10:e0143798
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Y 11
Average Rating: 5 (Based on 1 Review)
Have you used Y 11?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Pharmacological antagonists of FAK for 4 h before RNA or protein isolation FAK antagonists were Y11