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Y 11

  ( 2 citations )    
Product Datasheet
Catalog Number:4498
Chemical Name:1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide
Product Details
Citations (2)
Reviews
Biological Activity
Potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
Technical Data
  • M.Wt:
    265.15
  • Formula:
    C8H17N4OBr
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    1086639-59-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Y 11 include:

2 Citations: Showing 1 - 2
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  1. Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.
    Authors: Brown Et al.
    Mol Cancer Res  2015;13:78
  2. Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields.
    Authors: Robinson Et al.
    PLoS One  2015;10:e0143798

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