Chemical Name: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[22.214.171.124,7]decane bromide
Biological ActivityPotent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [126.96.36.199,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonoge
Golubovskaya et al.
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth.
Golubovskaya et al.
Citations for Y 11
The citations listed below are publications that use Tocris products. Selected citations for Y 11 include:
3 Citations: Showing 1 - 3
Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Authors: Keasey Et al.
J Cell Sci 2018;131
Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.
Authors: Brown Et al.
Mol Cancer Res 2015;13:78
Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields.
Authors: Robinson Et al.
PLoS One 2015;10:e0143798
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Pharmacological antagonists of FAK for 4 h before RNA or protein isolation FAK antagonists were Y11