Y-26763

Catalog # Availability Size / Price Qty
2076/10
2076/50
Y-26763 | CAS No. 127408-31-5 | Inward Rectifier Potassium Channel Activators
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Description: Kir6 (KATP) channel opener

Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide

Purity: ≥98%

Product Details
Supplemental Products
Reviews (1)

Biological Activity

Kir6 (KATP) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

Technical Data

M.Wt:
276.29
Formula:
C14H16N2O4
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at RT
CAS No:
127408-31-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Y-26763 was used to Kir2 channels to understand channel opening.
By Anonymous on 11/29/2018
Species: Human

Y-26763 was used to Kir2 inwardly-rectifying potassium channels expressed in HEK293 cell to understand the channel opening.


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