Y-26763

Tocris Bioscience | Catalog # 2076

Kir6 (KATP) channel opener
Tocris Bioscience
Discontinued Product
2076 has been discontinued. View all Inward Rectifier Potassium Channel Activators products.

Key Product Details

Description

Kir6 (KATP) channel opener
View all Inward Rectifier Potassium Channel Activators »

Product Description

Y-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

Product Specifications for Y-26763

Molecular Weight

276.29

Formula

C14H16N2O4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide

CAS Number

127408-31-5

PubChem ID

121878

InChI Key

IWTCFIIOUXJOOV-OLZOCXBDSA-N

SMILES

CC(=O)N(O)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 27.63 100

Preparing Stock Solutions for Y-26763

The following data is based on the product molecular weight 276.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.10 mL 36.19 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Y-26763

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Y-26763

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Y-26763 (1)

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  • Y-26763 was used to Kir2 channels to understand channel opening.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK 293
    Verified Customer | Posted 11/29/2018
    Y-26763 was used to Kir2 inwardly-rectifying potassium channels expressed in HEK293 cell to understand the channel opening.
    Y-26763 2076

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