Y-26763

   
Product Datasheet
Catalog Number:2076
Chemical Name:N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
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Biological Activity
Kir6 (KATP) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.
Technical Data
  • M.Wt:
    276.29
  • Formula:
    C14H16N2O4
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    127408-31-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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