Catalog Number: 2076
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
Biological Activity
Kir6 (KATP) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
    Nakajima et al.
    J.Pharmacol.Exp.Ther., 1992;261:730
  2. Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic β-cells
    Cosgrove et al.
    Eur.J.Pharmacol., 2004;486:133
  3. Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels
    Fukunari et al.
    Eur.J.Pharmacol., 1997;323:197
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