Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
Biological ActivityY-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.
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Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
Nakajima et al.
Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels
Fukunari et al.
Y-26763: ATP-sensitive K+ channel activation and the inhibition of Ins release from human pancreatic β-cells
Cosgrove et al.
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Y-26763 was used to Kir2 inwardly-rectifying potassium channels expressed in HEK293 cell to understand the channel opening.