Y-26763

Catalog # Availability Size / Price Qty
2076/10
2076/50
Y-26763 | CAS No. 127408-31-5 | Inward Rectifier Potassium Channel Activators
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Description: Kir6 (KATP) channel opener

Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide

Purity: ≥98%

Product Details
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Biological Activity

Y-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

Technical Data

M.Wt:
276.29
Formula:
C14H16N2O4
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at RT
CAS No:
127408-31-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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