YM 90709

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1675/10
YM 90709 | CAS No. 163769-88-8 | Cytokine Receptor Antagonists
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Description: Interleukin-5 receptor antagonist

Chemical Name: 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline

Purity: ≥99%

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Biological Activity

Novel, selective inhibitor of interleukin-5 (IL-5) (IC50 = 0.45 - 1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. Inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways in vivo, without affecting peripheral blood or bone marrow leukocytes.

Technical Data

M.Wt:
359.43
Formula:
C22H21N3O2
Solubility:
Soluble to 25 mM in ethanol and to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
163769-88-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Astellas Pharma Inc.

Product Datasheets

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