muscarinic receptor antagonist (pKi
values are 8.52, 7.93, 7.90 and 7.78 for M3
receptors respectively). Displays higher affinity at ileal M3
= 9.3) compared to oesophageal and tracheal M3
values are 8.8 and 8.2 respectively). Inhibits gastrointestinal motility in vivo
in the absence of cardiovascular effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists.
Life Sci., 1995;56:861
Characterization of the interaction of zamifenacin at muscarinic receptors in vitro.
Watson et al.
Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains.