Catalog Number: 0180
Chemical Name: (Z)-3-[(Aminoiminomethyl)thio]prop-2-enoic acid sulfate
Biological Activity
More potent than either GABA or muscimol as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. Also a GABAA-ρ receptor antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Isothiouronium compounds as γ-aminobutyric acid agonists.
    Allan et al.
    Br.J.Pharmacol., 1986;88:379
  2. ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell.
    Holden-Dye and Walker
    Br.J.Pharmacol., 1988;95:3
  3. GABAC receptors: relatively simple transmitter-gated ion channels?
    TiPS, 1996;17:319

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