Catalog Number: 3975
Chemical Name: (3S,11E)-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Biological Activity
Mycotoxin produced by several species of Fusarium fungi. Binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and stimulates the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Also stimulates growth of T47D breast cancer cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β.
    Kuiper et al.
    Endocrinology, 1998;139:4252
  2. Effects of zearalenone and α-Zearalenol in comparison with Raloxifene on T47D cells.
    Khosrokhavar et al.
    Toxicol.Mech.Methods, 2009;19:246
  3. Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro.
    Takemura et al.
    J.Steroid Biochem.Molec.Biol., 2007;103:170
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