Zearalenone

Catalog # Availability Size / Price Qty
3975/10
3975/50
Additional Estrogen and Related Receptor Compounds Small Molecule
1 Image
Description: Estrogen receptor ligand; mycotoxin

Chemical Name: (3S,11E)-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

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Biological Activity

Mycotoxin produced by several species of Fusarium fungi. Binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and stimulates the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Also stimulates growth of T47D breast cancer cells.

Technical Data

M.Wt:
318.36
Formula:
C18H22O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at -20°C
CAS No:
17924-92-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β.
    Kuiper et al.
    Endocrinology, 1998;139:4252
  2. Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro.
    Takemura et al.
    J.Steroid Biochem.Molec.Biol., 2007;103:170
  3. Effects of zearalenone and α-Zearalenol in comparison with ralox. on T47D cells.
    Khosrokhavar et al.
    Toxicol.Mech.Methods, 2009;19:246

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