5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC50
values are 0.33, 8.2 and 12 μ
M respectively). Modulates nociception and induces hyperglycemia in vivo
, and is an orally active antidepressant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor.
Ogren et al.
Acta Psychiatr.Scand.Suppl., 1981;290:127
Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and substance P behavioural assay.
Fasmer et al.
Involvement of serotonin in zimelidine-induced hyperglycemia in mice.
Sugimoto et al.
The citations listed below are publications that use Tocris products. Selected citations for Zimelidine dihydrochloride include:
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