Zimelidine dihydrochloride

Key Product Details

Product Description

5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC₅₀ values are 0.33, 8.2 and 12 μM respectively). Modulates nociception and induces hyperglycemia in vivo, and is an orally active antidepressant.

Product Specifications for Zimelidine dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Zimelidine dihydrochloride

The following data is based on the product molecular weight 390.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.82 mL	25.63 mL
5 mM	0.51 mL	2.56 mL	5.13 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Fasmer Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and substance P behavioural assay. Neuropharmacology 1987 PMID: 2438584
• Sugimoto Involvement of serotonin in zimelidine-induced hyperglycemia in mice. Biol.Pharm.Bull. 1999 PMID: 10598036
• Ogren The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor. Acta Psychiatr.Scand.Suppl. 1981 PMID: 6452789

Product Documents for Zimelidine dihydrochloride