hh Zimelidine dihydrochloride (CAS 60525-15-7): R&D Systems
Catalog Number: 1767
Chemical Name: (2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyrindinyl)-2-propen-1-amine dihydrochloride
Biological Activity
5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC50 values are 0.33, 8.2 and 12 μM respectively). Modulates nociception and induces hyperglycemia in vivo, and is an orally active antidepressant.
Technical Data
  • M.Wt:
    390.15
  • Formula:
    C16H17BrN2.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    60525-15-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor.
    Ogren et al.
    Acta Psychiatr.Scand.Suppl., 1981;290:127
  2. Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and substance P behavioural assay.
    Fasmer et al.
    Neuropharmacology, 1987;26:309
  3. Involvement of serotonin in zimelidine-induced hyperglycemia in mice.
    Sugimoto et al.
    Biol.Pharm.Bull., 1999;22:1240
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Zimelidine dihydrochloride include:

1 Citations: Showing 1 - 1

  1. A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation.
    Authors: Kim Et al.
    PLoS One 2009;4:e6044

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