ZM 447439

Tocris Bioscience | Catalog # 2458

Inhibits Aurora kinase B
Tocris Bioscience

Key Product Details

Description

Inhibits Aurora kinase B
View all Aurora Kinase Inhibitors »

Product Description

ZM 447439 is a novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for ZM 447439

Molecular Weight

513.59

Formula

C29H31N5O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide

CAS Number

331771-20-1

PubChem ID

9914412

InChI Key

OGNYUTNQZVRGMN-UHFFFAOYSA-N

SMILES

COC1=CC2=C(NC3=CC=C(NC(=O)C4=CC=CC=C4)C=C3)N=CN=C2C=C1OCCCN1CCOCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.36 100

Preparing Stock Solutions for ZM 447439

The following data is based on the product molecular weight 513.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 198 publications citing the usage of this product.

Product Documents for ZM 447439

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ZM 447439

For research use only

Related Research Areas

Cell Cycle
Epigenetics

Customer Reviews for ZM 447439 (1)

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  • ZM447439 releases cells into mitosis
    Name: Valeria Marotta
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: U2OS
    Verified Customer | Posted 10/07/2020
    The product was used to release the cells in mitosis after STLC clock
    ZM 447439 2458

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