Catalog Number: 2458
Chemical Name: N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Biological Activity
Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.
    Ditchfield et al.
    J.Cell Biol., 2003;161:267
  2. Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.
    Jung et al.
    J.Med.Chem., 2006;49:955
  3. Validating Aurora B as an anti-cancer drug target.
    Girdler et al.
    J.Cell Sci., 2006;119:3664

The citations listed below are publications that use Tocris products. Selected citations for ZM 447439 include:

Showing Results 1 - 10 of 25

  1. Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells.
    Authors: Tauchman Et al.
    J Cell Sci
  2. Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes.
    Authors: Platani Et al.
    J Cell Biol
  3. Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.
    Authors: Kim and Yu
    J Cell Biol
  4. Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na.
    Authors: Mäki-Jouppila Et al.
    Nat Commun
  5. Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes.
    Authors: Balboula and Schindler
    PLoS Genet
  6. Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis.
    Authors: Ferreira Et al.
    J Cell Biol
  7. Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.
    Authors: Floyd Et al.
    Cell Cycle
  8. Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.
    Authors: Wang Et al.
    J Cell Biol
  9. Aurora kinase B activity is modulated by thyroid hormone during transcriptional activation of pituitary genes.
    Authors: Tardáguila Et al.
    Mol Endocrinol
  10. Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.
    Authors: Kasuboski Et al.
    Mol Biol Cell
  11. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.
    Authors: Yuan Et al.
    Am J Pathol
  12. Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.
    Authors: Foley Et al.
    Nat Cell Biol
  13. Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly.
    Authors: Pal Et al.
    J Am Soc Nephrol
  14. VHL inactivation induces HEF1 and Aurora kinase A.
    Authors: Xu Et al.
    J Cell Biol
  15. Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase.
    Authors: Vázquez-Novelle and Petronczki
    Curr Biol
  16. Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission.
    Authors: Bastos and Barr
    J Cell Biol
  17. Release of Mps1 from kinetochores is crucial for timely anaphase onset.
    Authors: Jelluma Et al.
    Cell Cycle
  18. Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors.
    Authors: Bassett Et al.
    Mol Cancer Ther
  19. Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
    Authors: Manchado Et al.
    Cancer Cell
  20. Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.
    Authors: Samoshkin Et al.
    PLoS One
  21. Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks.
    Authors: Scutt Et al.
    J Biol Chem
  22. The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex.
    Authors: Platani Et al.
    Mol Biol Cell
  23. Cell cycle dependent degradation of MCAK: evidence against a role in anaphase chromosome movement.
    Authors: Ganguly Et al.
    Toxins (Basel)
  24. A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin.
    Authors: Slawson Et al.
    Mol Biol Cell
  25. Frequent overexpression of aurora B kinase, a novel drug target, in non-small cell lung carcinoma patients.
    Authors: Vischioni Et al.
    Mol Cancer Ther
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