ZNF198 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-84685

Novus Biologicals
100% Guarantee

Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (98%), Rat (98%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all ZNF198 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RLSFGTVFRHWKKNPLTMENKACLRYQVSSLCGTDNEDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQN

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23435261)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ZNF198 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: ZNF198 Antibody [NBP1-84685]

Immunocytochemistry/ Immunofluorescence: ZNF198 Antibody [NBP1-84685]

Immunocytochemistry/Immunofluorescence: ZNF198 Antibody [NBP1-84685] - Staining of human cell line A-431 shows localization to nucleoplasm & endoplasmic reticulum.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685] - Staining of human liver shows very weak positivity in hepatocytes.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685] - Staining of human testis shows strong nuclear positivity in cells of seminiferus ducts.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685] - Staining of human cerebral cortex shows moderate to strong positivity in neurons.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685] - Staining in human testis and liver tissues.. Corresponding ZMYM2 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685] - Staining of human testis shows moderate to strong nuclear positivity in cells in seminiferous ducts.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685] - Staining of human breast shows moderate nuclear positivity in glandular cells.

Applications for ZNF198 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ZNF198

Official Gene Symbol: ZMYM2 Gen Bank Accession Number: NP_932072 Gene ID: 7750 (Human) Gene Map Locus: 13q11-q12 (Human) ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.

Alternate Names

FIMRAMPSCLL, Fused in myeloproliferative disorders protein, MYM, Rearranged in atypical myeloproliferative disorder protein, Zinc finger protein 198rearranged in an atypical myeloproliferative disorder, zinc finger, MYM-type 2, ZNF198zinc finger MYM-type protein 2

Gene Symbol

ZMYM2

Additional ZNF198 Products

Product Documents for ZNF198 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for ZNF198 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for ZNF198 Antibody - BSA Free

Customer Reviews for ZNF198 Antibody - BSA Free

There are currently no reviews for this product. Be the first to review ZNF198 Antibody - BSA Free and earn rewards!

Have you used ZNF198 Antibody - BSA Free?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs

No product specific FAQs exist for this product.

View all FAQs for Antibodies