Catalog Number: 0655
Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
Biological Activity
Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors.
    Arbilla et al.
    Eur.J.Pharmacol., 1986;130:257
  2. Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects.
    Depoortere et al.
    J.Pharmacol.Exp.Ther., 1986;237:649
  3. Mechanism of action of the hypnotic zolpidem in vivo.
    Crestani et al.
    Br.J.Pharmacol., 2000;131:1251
  4. Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem.
    Perrault et al.
    J.Pharmacol.Exp.Ther., 1992;263:298

The citations listed below are publications that use Tocris products. Selected citations for Zolpidem include:

5 Citations: Showing 1 - 5
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  1. Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin
    Authors: Letra-Vilela Et al.
    Molecular and Cellular Endocrinology 2016;434:238
  2. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
    Authors: Seifi Et al.
    Br J Cancer 2014;34:10361
  3. Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity.
    Authors: Lazarus and Huang
    J Neurophysiol 2011;106:775
  4. Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex.
    Authors: Kotak Et al.
    J Neurosci 2008;18:2098
  5. Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
    Authors: Bowser Et al.
    Proc Natl Acad Sci U S A 2002;99:15170

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