Catalog Number: 0655
Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
Biological Activity
Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors.
    Arbilla et al.
    Eur.J.Pharmacol., 1986;130:257
  2. Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects.
    Depoortere et al.
    J.Pharmacol.Exp.Ther., 1986;237:649
  3. Mechanism of action of the hypnotic zolpidem in vivo.
    Crestani et al.
    Br.J.Pharmacol., 2000;131:1251
  4. Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem.
    Perrault et al.
    J.Pharmacol.Exp.Ther., 1992;263:298
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