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Common Macrophage Markers

Tissue-resident macrophages are a heterogeneous group of cells that express a variety of cell surface and intracellular markers. Although their markers frequently differ based on their anatomical locations and functions, there is some overlap in the markers that are expressed on different macrophage subpopulations. Some common receptors expressed on multiple mouse macrophage subpopulations include CD115/M-CSF R, F4/80, CD11b/Integrin alpha M, CD68, CD163, and Fc receptors. There are also a number of receptors that have been implicated in phagocytosis or ligand recognition that are frequently expressed by macrophages including scavenger receptors, toll-like receptors (TLRs), Nod-like receptors (NLRs), and some C-type lectin receptors.