Galectin-3, also known as Mac-2, L29, CBP35, and etaBP, is a secreted lectin that acts in anti-microbial immunity by pathogen opsonization, macrophage recruitment, and the activation of mast cells and neutrophils. It can also contribute to chronic inflammation and fibrosis. It is implicated in neuroinflammatory disorders of the central nervous system, cardiac fibrosis, and heart failure, as well as tumor growth, progression, and metastasis.
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