Diabetes Mellitus is a metabolic syndrome in which patients do not produce sufficient levels of, or correctly respond to, insulin. Secreted from beta-cells in the islets of Langerhans in the pancreas, insulin is an essential physiological hormone. Under normal physiological conditions, insulin is secreted in response to increased blood glucose levels, stimulates cellular glucose uptake and subsequent storage as glycogen. Type-1 diabetes is characterized by a failure to produce enough insulin. In contrast, insulin is released during type-2 and gestational diabetes, but the body exhibits insulin resistance and fails to respond accordingly. Although the specific cause remains unknown, type-1 diabetes is believed to result following autoimmune destruction of pancreatic beta-cells. Increased risk of developing type-2 diabetes is more commonly associated with lifestyle factors, such as obesity. R&D Systems offers a range of quality products to study biological processes underlying diabetes, including glucose transport, insulin signaling, and inflammation.