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HRPs (HDGF-related Proteins) and HDGF (Hepatoma-derived Growth Factor) are members of the HDGF family of proteins. There are currently six family members that vary widely in size. All lack a canonical signal sequence but appear to be secreted. In addition, family members possess a nuclear localization signal and a signature 90-100 amino acid, N-terminal hath region that contains a conserved PWWP motif.