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Leukotriene A4 Hydrolase/LTA4

Leukotriene A4 Hydrolase catalyzes the conversion of unstable epoxide Leukotriene A4 (LTA4) to Leukotriene B4 (LTB4). It is highly specific for LTA4, which also covalently modifies and inhibits the enzyme. As a bifunctional zinc metalloenzyme, LTA4H also acts as an arginyl aminopeptidase. LTA4H is a drug target for inflammation, and for cancer prevention and therapy.