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Mesenchymal Stem Cell Transcription Factors

Mesenchymal Stem Cells (MSCs) differentiate into diverse cell types including adipocytes, cardiomyocytes, chondrocytes, and osteoblasts. The development of these cell types is influenced by the expression of various transcription factors within MSC populations. For example, Smad family members are important for chondrogenic differentiation, and Forkhead box (Fox) proteins promote osteogenesis. In addition, transcription factors, such as SOX2, are important regulators of mesenchymal stem cell self-renewal capacity and multipotency.